Patient engagement

Beyond eligibility. Activating real participation.

Clinical trial recruitment today identifies who qualifies biologically, but fails to account for whether a person is able, willing, or prepared to participate. Gryt bridges that gap.

Key takeaway

CTPA augments diagnosis-based eligibility with lived-experience intelligence to activate, and sustain, real clinical trial participation. Over the past decade, it has successfully enrolled high-priority trials and helped clients achieve FDA goals.

The problem

Eligibility criteria miss the full picture

Static inclusion and exclusion criteria identify who qualifies biologically, but ignore whether a patient is able, willing, or prepared to participate. This diagnosis-only approach drives costly enrollment delays, protocol amendments, and early dropouts.

Diagnosis-only model

Who qualifies biologically?

  • Focuses on diagnosis, biomarkers, and clinical attributes
  • Static inclusion and exclusion criteria only
  • Does not account for lived experience or readiness
  • High rates of non-enrollment, early disengagement, and dropout
  • Costly recruitment delays and protocol amendments
Gryt’s CTPA model

Who will enroll, engage, and complete?

  • Augments clinical criteria with lived-experience intelligence
  • Identifies behavioral readiness and participation barriers
  • Surfaces actionable interventions to increase activation
  • Improves retention across the full trial lifecycle
  • Especially effective for precision medicine, rare disease, and hard-to-reach populations

The result: many eligible patients do not enroll, disengage early, or drop out, especially in precision medicine, rare disease, and underrepresented populations. By integrating lived-experience intelligence with clinical eligibility, CTPA enables participation-ready recruitment.

Track record

A decade of proven results

Years activating patients
10+
SCOPE Participant Engagement Award
2×
Goals achieved for clients
FDA
2016
Gryt Health founded

Co-founded by David Craig following experience at Lilly COI and leading LIVESTRONG’s Clinical Trial Matching Service.

2017
First client: Ignyta NTRK trial

Gryt’s first client engagement successfully supported enrollment of Ignyta’s landmark NTRK clinical trial.

2019
SCOPE Participant Engagement Award

Recognized at SCOPE 2019 for industry-leading work in patient engagement and clinical trial participation.

2021
SCOPE Award, second recognition

Awarded again at SCOPE 2021, cementing Gryt’s reputation as a leader in participant-centered trial engagement.

Now
Expanding CTPA across precision medicine

Advancing lived-experience intelligence as a core driver of trial success across rare disease, oncology, and underrepresented populations.

How CTPA works

A proven solution for recruitment and representation

Our approach

  1. Position clinical trials with clearly articulated differentiators
  2. Increase awareness with physicians and patients based on targeted geographic and demographic factors, particularly for underrepresented patients
  3. Use a scalable approach with real-time engagement and conversion analytics
  4. Demonstrate results and optimize efforts with bi-weekly reporting

Outcomes achieved

  • Patient-focused trial education, boosting awareness and screening
  • Engaged underrepresented patients by race, ethnicity, and rural setting
  • Actionable insights and analytics for overall and site-specific recruitment
  • Increased patient diversity in screening
  • KPIs used to complete the read-out for FDA Diversity Action Plans
Map of US trial sites with 200-mile radii and engagement pins from a Gryt CTPA campaign

Engagement by site location. Each pin is a person who searched, saw the campaign, used Gryt’s engagement platform, and took action toward enrollment.